We explored how L-glutamine affects liver health in ob/ob mice, specifically looking at its antioxidant and anti-inflammatory properties. Over 40 days, mice received either L-alanyl-L-glutamine or free L-glutamine, while control mice drank just water.
Our findings showed that the L-alanyl-L-glutamine group experienced improved insulin sensitivity and reduced liver fat. Although free L-glutamine raised muscle glutamine levels, it had less impact on overall insulin resistance. Ultimately, boosting glutamine levels helped mitigate oxidative stress and inflammation linked to obesity.
Read More
4
Potential muscle mass maintenance
An open-label, randomized, controlled trial on the benefit of β-hydroxy-β-methyl butyrate, l-arginine, l-glutamine combination beverages and locomotion training as supportive care for the treatment of unresectable hepatocellular carcinoma using lenvatinib: A pilot study (HELLO study).
We looked into the effectiveness of a beverage combining β-hydroxy-β-methyl butyrate, l-arginine, and l-glutamine, along with locomotion training, for patients undergoing treatment for unresectable hepatocellular carcinoma using lenvatinib.
In a pilot study involving 20 patients, we found that while the combination drink didn’t reduce hand-foot-skin reactions—one of the common side effects—it may help in preserving muscle mass. Thus, further research with a larger group is needed to confirm these results.
Read More
Most Useful Reviews
9
Detox support
9 people found this helpful
I use it with glycine, cysteine, NAC, and vitamin C to produce glutathione, acting as an antioxidant to cleanse the liver and body of toxins. If you find this review helpful, please click the Like button.
Read More
9
Reflux improvement
7 people found this helpful
This product has tremendously helped my terrible reflux and oesophagitis. I had taken NEXIUM but found it caused various other issues, so I stopped. The burning was severe initially, but taking Now Foods L-Glutamine a couple of times a day, just before or after meals, has allowed me to rarely experience reflux now. A fantastic product with super fast delivery thanks to iHerb and DHL.
Read More
7.5
Eases symptoms
6 people found this helpful
Great! I have leaky gut syndrome, which gives me all sorts of symptoms, including food allergies. This eases them up.
We explored how L-glutamine affects liver health in ob/ob mice, specifically looking at its antioxidant and anti-inflammatory properties. Over 40 days, mice received either L-alanyl-L-glutamine or free L-glutamine, while control mice drank just water.
Our findings showed that the L-alanyl-L-glutamine group experienced improved insulin sensitivity and reduced liver fat. Although free L-glutamine raised muscle glutamine levels, it had less impact on overall insulin resistance. Ultimately, boosting glutamine levels helped mitigate oxidative stress and inflammation linked to obesity.
Read More
4
Potential muscle mass maintenance
An open-label, randomized, controlled trial on the benefit of β-hydroxy-β-methyl butyrate, l-arginine, l-glutamine combination beverages and locomotion training as supportive care for the treatment of unresectable hepatocellular carcinoma using lenvatinib: A pilot study (HELLO study).
We looked into the effectiveness of a beverage combining β-hydroxy-β-methyl butyrate, l-arginine, and l-glutamine, along with locomotion training, for patients undergoing treatment for unresectable hepatocellular carcinoma using lenvatinib.
In a pilot study involving 20 patients, we found that while the combination drink didn’t reduce hand-foot-skin reactions—one of the common side effects—it may help in preserving muscle mass. Thus, further research with a larger group is needed to confirm these results.
Read More
User Reviews
USERS' SCORE
Good
Based on 11 Reviews
8.1
All Reviews
Positive Reviews
Negative Reviews
9
Detox support
9 people found this helpful
I use it with glycine, cysteine, NAC, and vitamin C to produce glutathione, acting as an antioxidant to cleanse the liver and body of toxins. If you find this review helpful, please click the Like button.
Read More
9
Reflux improvement
7 people found this helpful
This product has tremendously helped my terrible reflux and oesophagitis. I had taken NEXIUM but found it caused various other issues, so I stopped. The burning was severe initially, but taking Now Foods L-Glutamine a couple of times a day, just before or after meals, has allowed me to rarely experience reflux now. A fantastic product with super fast delivery thanks to iHerb and DHL.
Read More
7.5
Eases symptoms
6 people found this helpful
Great! I have leaky gut syndrome, which gives me all sorts of symptoms, including food allergies. This eases them up.
Read More
7.5
Healing support
5 people found this helpful
This product is reputed to aid intestinal healing, particularly for individuals with Crohn's disease, which is why I use it. Combining it with wormwood, ashwagandha, and Boswellia has significantly improved my health. I also incorporate Reishi in the evening, panax ginseng in the afternoon, and rhodiola in the morning. Maintaining a healthy diet and mindset, along with these supplements, fosters overall well-being.
Read More
6
Boosts immunity and recovery
3 people found this helpful
Glutamine, when combined with taurine, enhances recovery and immunity. As protein is broken down into glutamine, excess intake can improve muscle resilience and intestinal health. Taurine also supports liver function and fatigue recovery. For optimal recovery, it's advised to combine both supplements, particularly after intense exercises.
Liver disease encompasses a variety of conditions that affect the liver's ability to function effectively. The liver is a vital organ responsible for many important tasks, including metabolizing nutrients, detoxifying harmful substances, and producing bile for digestion. Common forms of liver disease include hepatitis, fatty liver disease, cirrhosis, and liver cancer. Each of these conditions can significantly impact liver function and overall health, leading to symptoms that range from fatigue and jaundice to more serious complications requiring urgent medical attention.
The causes of liver disease are diverse and can include chronic alcohol abuse, viral infections, autoimmune disorders, and metabolic conditions like obesity and diabetes. Early detection is key to managing liver disease effectively, often involving lifestyle changes, medications, and sometimes surgical interventions. Regular check-ups and liver function tests are recommended for individuals at higher risk, such as those with a family history of liver disease or those who lead certain lifestyle habits. Adopting a balanced diet and reducing alcohol intake can greatly aid in liver health and help prevent the onset of these conditions.
L-glutamine is an amino acid that is classified as a conditionally essential amino acid, meaning that while the body usually produces enough of it, there may be times — like during illness, injury, or intense physical activity — when supplementation can be beneficial. It plays a crucial role in various physiological functions, including protein synthesis, immune system support, and maintaining gut health. Glutamine is particularly important for athletes and those engaging in heavy workouts, as it can help in muscle recovery and reduce muscle soreness after exercise.
In terms of dietary sources, L-glutamine is naturally found in high-protein foods such as beef, chicken, fish, eggs, dairy products, and certain plant-based foods like beans, lentils, and spinach. Many people choose to take L-glutamine supplements to bolster their intake, particularly when they are involved in rigorous training or are recovering from surgery or trauma. However, as with any supplement, it’s advisable to consult healthcare professionals before starting to ensure it aligns with your health needs and dietary goals.
Based on user reviews regarding the use of glutamine for liver health, the timeline for seeing results can vary. Several users have reported significant benefits shortly after they began taking the supplement. For instance, one reviewer noted a noticeable improvement in their gastrointestinal health and reduction in symptoms like heartburn and bloating after using it for a short period Read Review. Another user highlighted the importance of glutamine for bowel health and expressed optimism for a swift recovery upon starting the supplement Read Review.
However, individual experiences may vary and the timeframe for benefits can depend on various factors, such as dosage and personal health conditions. Users generally emphasize consistency in supplementation, suggesting that while some relief may be felt quickly, ongoing use may be necessary for sustained improvement in liver health and overall digestive function Read Review. As always, for personalized advice, it's best to consult a healthcare professional.
This supplement, particularly L-glutamine, shows some promise based on scientific research regarding liver health. One study demonstrated that L-glutamine supplementation improved insulin sensitivity and reduced liver fat in mice with obesity traits, indicating potential protective effects against oxidative stress and inflammation related to liver conditions [1]. However, it's essential to consider that much of this research is preclinical and conducted on animal models, so results may not fully translate to human outcomes.
In terms of its role in liver cancer care, a pilot study involving a combination of l-glutamine among other substances for patients with unresectable hepatocellular carcinoma offered some insights. While no significant reduction in side effects was noted, the study suggested that L-glutamine might help preserve muscle mass during treatment [2]. These findings underscore the need for further research to ascertain L-glutamine's effectiveness and appropriate applications in human liver disease management.
Users have reported a range of improvements in their health symptoms, particularly relating to digestive issues and intestinal health. One reviewer noted a significant reduction in severe reflux and esophagitis symptoms after using glutamine, allowing them to "rarely experience reflux now" Read Review. Another user with leaky gut syndrome mentioned that glutamine helped ease their symptoms of food allergies, showcasing its potential in improving gastrointestinal issues Read Review. Similarly, users with Crohn's disease reported enhancements in their bowel health and overall well-being, attributing their improved conditions to this supplement Read Review.
While many users have shared positive experiences, including an increase in digestive regularity and recovery from gut-related ailments, it's important to recognize that individual results can vary significantly based on personal health conditions and other supplements used in conjunction Read Review. Some health benefits were also seen after a prolonged usage, emphasizing the potential need for consistency in supplementation for optimal results Read Review. As always, it’s advisable to consult with a healthcare professional for personalized guidance.
Based on user reviews, many individuals have reported positive experiences when combining glutamine with various supplements to support liver health. One user mentioned taking glutamine alongside glycine, cysteine, NAC, and vitamin C to boost the production of glutathione, a crucial antioxidant for liver detoxification and overall health Read Review. Another user noted enhancements in health while using glutamine together with wormwood, ashwagandha, and Boswellia, emphasizing a holistic approach to well-being that included dietary considerations Read Review.
Additionally, users have reported that combining glutamine with taurine can enhance recovery and support liver function, especially after strenuous activities Read Review. Overall, it seems that many find that using glutamine in conjunction with other supplements not only bolsters liver health but also contributes to broader digestive and immune support Read Review. However, users might have varying experiences depending on personal health conditions and the specific combinations used.
Based on user reviews, there seems to be a variety of experiences concerning the dosage of L-Glutamine for treating liver disease and related health issues. Users recommend incorporating it with other supplements like glycine and taurine for maximum benefits. One review mentions that a specific dosage is beneficial for restoring intestinal health and is also considered good for the liver Read Review. Another user states that they began taking the supplement on their doctor's advice and reported improvements in gastrointestinal health and overall well-being post-COVID-19 Read Review.
While some reviews highlight personal success with L-Glutamine, they do not specify an exact dosage, indicating a reliance on individualized treatment plans. Users have mentioned taking varying doses throughout the day, with some taking two capsules at night and one in the morning Read Review. Therefore, while the reviews support L-Glutamine as a helpful supplement for liver health, they do not converge on a standardized dosage, suggesting that users should consider personal consultation with a healthcare provider for tailored advice.
7.5
Important for bowel health
5 people found this helpful
Living with Crohn's disease, I’ve avoided immunosuppressive treatments and relied heavily on supplements to reclaim a normal life. Glutamine is crucial for my bowel health, and I was pleasantly surprised by the attractive packaging. I began taking it today, hoping for a swift recovery.
7.5
Liver restoration
This dosage has been beneficial for restoring my intestines and is also good for the liver, as I saw recommended.
9
Reflux improvement
7 people found this helpful
This product has tremendously helped my terrible reflux and oesophagitis. I had taken NEXIUM but found it caused various other issues, so I stopped. The burning was severe initially, but taking Now Foods L-Glutamine a couple of times a day, just before or after meals, has allowed me to rarely experience reflux now. A fantastic product with super fast delivery thanks to iHerb and DHL.
7.5
Eases symptoms
6 people found this helpful
Great! I have leaky gut syndrome, which gives me all sorts of symptoms, including food allergies. This eases them up.
7.5
Healing support
5 people found this helpful
This product is reputed to aid intestinal healing, particularly for individuals with Crohn's disease, which is why I use it. Combining it with wormwood, ashwagandha, and Boswellia has significantly improved my health. I also incorporate Reishi in the evening, panax ginseng in the afternoon, and rhodiola in the morning. Maintaining a healthy diet and mindset, along with these supplements, fosters overall well-being.
7.5
Improved bowel movements
I started taking glutamine after learning it could enhance my gut health. As I age, my bowel movements have slowed, causing discomfort. Since beginning this supplement, I've noticed improvement in my digestive regularity. The capsules are sizable but manageable. I typically take two at night and one in the morning, which has made a positive difference, and I appreciate the quality of the natural ingredients.
7.5
Eases outbreaks
This has helped to ease outbreaks of my leaky gut syndrome significantly.
9
Detox support
9 people found this helpful
I use it with glycine, cysteine, NAC, and vitamin C to produce glutathione, acting as an antioxidant to cleanse the liver and body of toxins. If you find this review helpful, please click the Like button.
6
Boosts immunity and recovery
3 people found this helpful
Glutamine, when combined with taurine, enhances recovery and immunity. As protein is broken down into glutamine, excess intake can improve muscle resilience and intestinal health. Taurine also supports liver function and fatigue recovery. For optimal recovery, it's advised to combine both supplements, particularly after intense exercises.
8
L-glutamine supports liver function
Liver lipid metabolism, oxidative stress, and inflammation in glutamine-supplemented ob/ob mice.
We explored how L-glutamine affects liver health in ob/ob mice, specifically looking at its antioxidant and anti-inflammatory properties. Over 40 days, mice received either L-alanyl-L-glutamine or free L-glutamine, while control mice drank just water.
Our findings showed that the L-alanyl-L-glutamine group experienced improved insulin sensitivity and reduced liver fat. Although free L-glutamine raised muscle glutamine levels, it had less impact on overall insulin resistance. Ultimately, boosting glutamine levels helped mitigate oxidative stress and inflammation linked to obesity.
4
Potential muscle mass maintenance
An open-label, randomized, controlled trial on the benefit of β-hydroxy-β-methyl butyrate, l-arginine, l-glutamine combination beverages and locomotion training as supportive care for the treatment of unresectable hepatocellular carcinoma using lenvatinib: A pilot study (HELLO study).
We looked into the effectiveness of a beverage combining β-hydroxy-β-methyl butyrate, l-arginine, and l-glutamine, along with locomotion training, for patients undergoing treatment for unresectable hepatocellular carcinoma using lenvatinib.
In a pilot study involving 20 patients, we found that while the combination drink didn’t reduce hand-foot-skin reactions—one of the common side effects—it may help in preserving muscle mass. Thus, further research with a larger group is needed to confirm these results.
References
Leite JSM, Vilas-Boas EA, Takahashi HK, Munhoz AC, Araújo LCC, et al. Liver lipid metabolism, oxidative stress, and inflammation in glutamine-supplemented ob/ob mice. J Nutr Biochem. 2025;138:109842. 10.1016/j.jnutbio.2025.109842
Naganuma A, Makita F, Sugimoto R, Kikuchi M, Furuta K, et al. An open-label, randomized, controlled trial on the benefit of β-hydroxy-β-methyl butyrate, l-arginine, l-glutamine combination beverages and locomotion training as supportive care for the treatment of unresectable hepatocellular carcinoma using lenvatinib: A pilot study (HELLO study). Clin Nutr ESPEN. 2025;65:357. 10.1016/j.clnesp.2024.12.005